Hyzaar: What It Is and How to Use It Safely

Hyzaar combines losartan (an ARB) with hydrochlorothiazide (a diuretic) to lower blood pressure two ways: relaxing blood vessels and reducing fluid volume. That combo can help people whose blood pressure isn’t controlled by a single drug. If your doctor prescribed Hyzaar, this page gives clear, practical tips on how to take it, what to watch for, and common interactions.

How Hyzaar works and who should take it

Losartan blocks a hormone that tightens blood vessels. Hydrochlorothiazide helps kidneys remove salt and water. Together they often reduce systolic and diastolic blood pressure more than either drug alone. Doctors typically choose Hyzaar for patients with essential hypertension who need extra control, and sometimes for people who respond well to ARBs but need a diuretic added. It’s not a first choice in pregnancy — tell your doctor if you’re pregnant or planning pregnancy.

Start with the dose your doctor gives and stick to it. Many people take Hyzaar once daily, usually in the morning because the diuretic can make you pee more. If you miss a dose, take it when you remember unless it’s near the next dose; don’t double up. Keep a record of home blood pressure readings and bring them to appointments — that helps your prescriber fine-tune the dose.

Side effects, interactions, and practical tips

Common side effects include dizziness (especially when standing up), increased urination, and lightheadedness. Because losartan can lower potassium, while diuretics can lower sodium and potassium, your doctor may check blood tests for electrolytes and kidney function within a few weeks of starting or changing dose. Rare but serious issues include allergic swelling (angioedema) and kidney problems — seek care if you get facial swelling, trouble breathing, or very low urine output.

Watch what you mix with Hyzaar. Avoid routine use of NSAIDs like ibuprofen if possible — they can blunt blood pressure control and stress the kidneys. Don’t start potassium supplements or salt substitutes without asking your doctor. Tell your provider about lithium, other blood pressure meds, or diabetes drugs, since interactions can matter.

Practical habits that help: take Hyzaar at the same time each day (morning is best for most), rise slowly from sitting to reduce dizziness, stay hydrated but avoid sudden large salt changes, and keep routine lab checks. If you have gout, note that hydrochlorothiazide may raise uric acid and trigger flares.

Want a deeper comparison? Read our piece on Losartan‑Hydrochlorothiazide vs other blood pressure medications to see how Hyzaar stacks up against ACE inhibitors, calcium‑channel blockers, and other options. If side effects or control are a problem, don’t stop suddenly — contact your prescriber for a plan to switch safely.

Questions about cost, generics, or alternatives? Hyzaar has generic forms that may lower cost, and many resources on our site cover alternatives and patient tips. Use those articles and your doctor’s advice together to get the best result for your blood pressure.